Once-Daily Levofloxacin Effective for Chronic Bacterial Prostatitis

“Aerobic gram-negative enteric bacteria (eg, Escherichia coli) have been recognized as the most prevalent etiologic agents of bacterial prostatitis, and the role of gram-positive bacteria has been controversial,” write William Bundrick, from Regional Urology in Shreveport, Louisiana, and colleagues. “Because of their broad orbit process and preferential accrual in prostatic matter, fluoroquinolones have become the post of care for chronic bacterial prostatitis.”

In this active-control tryout, 377 men with a record of chronic bacterial prostatitis, course clinical signs and symptoms, and research lab indication of prostatitis were randomized to discussion with levofloxacin 500 mg once daily or ciprofloxacin 500 mg twice daily for 28 days.
The primary winding end full stop was microbiologic efficacy.

The rate of clinical soul, defined as cured plus improved patients, was 75% for levofloxacin and 72.8% for ciprofloxacin (95% secret separation [CI] for the quality in the somebody rates, -13.27 to 8.87).
Microbiologic eradication rates were also similar in both groups (75% for levofloxacin and 76.8% for ciprofloxacin; 95% CI for the fluctuation, -8.98 to 12.58).
The most common isolates were Enterococcus faecalis and E. coli.
Both regimens were well tolerated, with similar rates of adverse events and of relapse by six months. Once-daily levofloxacin is as effective as ciprofloxacin 500mg
taken twice daily for 28 days for the attention of chronic bacterial
prostatitis, according to the results of a randomized, double-blind,
multicenter proceedings published in the September fund of Urology. Thoughtfulness limitations include continued symptoms in some patients in each direction building block contempt eradication of the pathogen at the posttherapy sojourn, and closing off of bacteria in some patients who were considered to have clinical mortal.

“This suggests that in chronic bacterial prostatitis, clinical cure and eradication of pathogens may not always correlate,” the authors write. “Isolation of a high equipoise of gram-positive organisms, as well as gram-negative pathogens, underscores the essential of choosing an antimicrobial causal agent with broad-spectrum trait.”

Ortho-McNeil Pharmaceutical, Inc., funded this document and several of its investigators.
Other contemplation authors are employees of, and hold stalk in, Ortho-McNeil.
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